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ChemicalBook CAS DataBase List METHYL 4,6-DICHLORO-QUINOLINE-2-CARBOXYLATE
848501-96-2

METHYL 4,6-DICHLORO-QUINOLINE-2-CARBOXYLATE synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: methanol / 0.25 h / 20 °C
2: Eaton′s Reagent / 2 h / 50 °C
3: phosphoryl chloride / 0.75 h / 100 °C

References:

Koester, Dennis C.;Marx, Vanessa M.;Williams, Sarah;Jiricek, Jan;Dauphinais, Maxime;René, Olivier;Miller, Sarah L.;Zhang, Lei;Patra, Debjani;Chen, Yen-Liang;Cheung, Harry;Gable, Jonathan;Lakshminarayana, Suresh B.;Osborne, Colin;Galarneau, Jean-Rene;Kulkarni, Upendra;Richmond, Wendy;Bretz, Angela;Xiao, Linda;Supek, Frantisek;Wiesmann, Christian;Honnappa, Srinivas;Be, Celine;M?ser, Pascal;Kaiser, Marcel;Ritchie, Ryan;Barrett, Michael P.;Diagana, Thierry T.;Sarko, Christopher;Rao, Srinivasa P. S. [Journal of Medicinal Chemistry,2022,vol. 65,# 17,p. 11776 - 11787]

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