ChemicalBook CAS DataBase List Methyl 3-amino-4-hydroxybenzoate

Methyl 3-amino-4-hydroxybenzoate synthesis

8synthesis methods

Product Name:Methyl 3-amino-4-hydroxybenzoate
CAS Number:536-25-4
Molecular formula:C8H9NO3
Molecular Weight:167.16

67-56-1 Synthesis

67-56-1
757 suppliers
$7.29/5ml-f

1571-72-8 Synthesis

1571-72-8
263 suppliers
$8.00/1g

536-25-4
192 suppliers
$11.00/250mg

Yield:536-25-4 100%

Reaction Conditions:

with sulfuric acid for 24 h;Reflux;

Steps:

Step1: preparation of methyl 4-amino-3-nitrobenzoate (12).
General procedure: Toa solution of 4-amino-3-nitrobenzoic acid (11, 500 mg, 2.75 mmol) inMeOH (20 mL), a catalytic amount of concentrated sulfuric acid was added in a dropwisefashion. The mixture was heated at reflux temperature overnight. After beingcooled, the reaction was quenched by saturated NaHCO₃solution andextracted by ethyl acetate.The organic layer was separated and dried over anhydroussodium sulfate. Filtration and concentrationin vacuogave 12 (519 mg, 97%); yellow solid

References:

Jaikhan, Pattaporn;Buranrat, Benjaporn;Itoh, Yukihiro;Chotitumnavee, Jiranan;Kurohara, Takashi;Suzuki, Takayoshi [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 10,p. 1173 - 1176] Location in patent:supporting information

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