Methyl 2-formylbenzoate synthesis
- Product Name:Methyl 2-formylbenzoate
- CAS Number:4122-56-9
- Molecular formula:C9H8O3
- Molecular Weight:164.16
Yield:4122-56-9 100%
Reaction Conditions:
with potassium carbonate in acetone at 20 - 56;
Steps:
Synthesis of methyl 4-chloroisoquinoline-2-carboxylate Synthesis of 2-carboxymethylbenzaldehyde: 2-Carboxybenzaldehyde (4.53g, 30mmoles) was dissolved in acetone (100mls) and anhydrous potassium carbonate (4.14g, 30mmoles) was added. After stirring methyl iodide (5.6mls, 90mmoles) was added and the reaction was heated (560C) for 30 minutes. The reaction became very thick so further acetone was added (50mIs) and stirring continued at room temperature for a further 72 hours. The reaction mixture was filtered through Celite and then evaporated to leave a viscous oil. The oil was then partitioned between water (30ml) and ethyl acetate (30ml). The aqueous layer was washed with further ethyl acetate (2x3 OmIs) and all the ethyl acetate extracts combined and washed with brine (30mIs) and then water (3OmIs) dried over anhydrous magnesium sulphate and evaporated to leave a clear light yellow oil (4.9g, 100% yield).
References:
QUEEN MARY AND WESTFIELD COLLEGE;COTTER, Finbarr, Edward WO2010/125343, 2010, A1 Location in patent:Page/Page column 35; 36
201230-82-2
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