METHYL 1-METHYL-2-IMIDAZOLINE-4-CARBOXYLATE synthesis
- Product Name:METHYL 1-METHYL-2-IMIDAZOLINE-4-CARBOXYLATE
- CAS Number:17289-17-7
- Molecular formula:C6H10N2O2
- Molecular Weight:142.16
Yield:-
Reaction Conditions:
in water;
Steps:
38 Dimethyl 5-methyl-2-(1-methyl-4-imidazolyl)pyrrole-3,4-dicarboxylate (38)
17.0 g of 38C was dissolved in 203 ml of anhydrous methanol and dry hydrogen chloride was bubbled rapidly into the mixture while it was heated to and at reflux for 2 hours. the mixture was cooled, stripped of volatiles, mixed with 300 ml of water, neutralized with solid sodium bicarbonate, made basic to pH=9 with 3N aqueous sodium carbonate solution. The aqueous phase was extracted with methylene chloride, the extract was dried (MgSO4), filtered and stripped of solvent, to give methyl 1-methylimidazoline-4-carboxylate (38D), as a brown oil.
References:
US4853027,1989,A