ChemicalBook CAS DataBase List M-ISOBUTYL IBUPROFEN

M-ISOBUTYL IBUPROFEN synthesis

6synthesis methods

Product Name:M-ISOBUTYL IBUPROFEN
CAS Number:66622-47-7
Molecular formula:C13H18O2
Molecular Weight:206.28

α-Methyl-3-(2-methylpropyl)-benzeneacetic Acid Methyl Ester

859828-57-2
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66622-47-7
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Yield:66622-47-7 95%

Reaction Conditions:

in methanol;water; pH=2 - 3 at 45; for 5 h;

Steps:

3 Example 3 Preparation of Ibuprofen Impurity A
To a 100 mL single-mouth bottle was added methyl 2-(3-isobutylphenyl)propanoate (1.99 g, 9 mmol, 1.0 eq), followed by a mixed solution of methanol/water (7:1, v:v) (20 mL) ), stirring and dissolving, and controlling the temperature at 45 ° C for 5 hours.The reaction was concentrated to dryness. EtOAc m.The liquid phase was separated, and the aqueous phase was adjusted to pH 2 to 3 with 1 N HCl.It was then extracted twice with dichloromethane (20 mL).The two subsequent dichloromethane extracts were combined and dried over anhydrous sodium sulfate.Concentrated to dry 1.72g of colorless transparent liquid, purity 99.8%, yield 95%,It is the ibuprofen impurity A.

References:

Shenzhen Xianggen Biological Technology Co., Ltd.;Peng Jinan;Li Fanglin;Zhang Qishan;Luo Yuting;Xiao Qicai;Gao Liqian CN108794319, 2018, A Location in patent:Paragraph 0040-0041

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