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ChemicalBook CAS DataBase List L-3-Chlorophenylalanine
80126-51-8

L-3-Chlorophenylalanine synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 1.) LDA / 1.) THF, hexane, -78 deg C, 40 min: 2.) THF, hexane, -78 deg C
2: 1.) trifluoroacetic acid; 2.) 0.75M HCl, Dowex 50-WX8, acetic acid / 1.) CH2Cl2, 30 min, 0 deg C; 12 h, room temperature; 2.) 100-105 deg C, toluene, water, 94 h

References:

Seebach, Dieter;Dziadulewicz, Edward;Behrendt, Linda;Cantoreggi, Sergio;Fitzi, Robert [Liebigs Annalen der Chemie,1989,p. 1215 - 1232]

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