Isobutanesulfonyl chloride synthesis
- Product Name:Isobutanesulfonyl chloride
- CAS Number:35432-36-1
- Molecular formula:C4H9ClO2S
- Molecular Weight:156.63
513-44-0
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Yield:35432-36-1 95%
Reaction Conditions:
Stage #1:2-methylpropanethiol-1 with sulfuryl dichloride;potassium nitrate in acetonitrile at 0; for 3 h;
Stage #2: with sodium hydrogencarbonate in water;acetonitrile
Steps:
2-Methyl-1-propanesulfonyl chloride
To [2-METHYL-1-PROPANETHIOL] (200 mg, 2.22 mmol) at [0C] in acetonitrile under nitrogen was added [KNOWS] (561 mg, 5.5 mmol) then sulfuryl chloride (0.45 ml, 5.5 mmol). The reaction mixture was stirred at [0C] for 3h, diluted with [NAHCO3] and extracted with ethyl acetate. The combined organic layers were washed with brine, dried [(MGS04)] and evaporated to give the sulfonyl chloride (293 mg, 95%)
References:
MERCK SHARP & DOHME LIMITED WO2004/31139, 2004, A1 Location in patent:Page 19
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