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ChemicalBook CAS DataBase List Fumaric acid
110-17-8

Fumaric acid synthesis

15synthesis methods
By the action of certain fungi (Rhizopus nigricans) on glucose; by oxidation of furfural with sodium chlorate in the pres- ence of vanadium pentoxide.
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Yield:110-17-8 99.5%

Reaction Conditions:

with maleic anhydride in lithium hydroxide monohydrate at 190; for 6 h;Inert atmosphere;Autoclave;Green chemistry;Reagent/catalyst;

Steps:

4

Saturated malic acid in the mother liquid and the water suction filtrate lossy process, the need to fill the filtrate in Example 3 plus a certain amount of the mass of 306g at a concentration of 50%, together with 300g of maleic anhydride was added to a 1000ml autoclave in with N2 Air autoclave was replaced three times at 190 degree, speed of 300 rev / min under conditions of reaction 6h, after the reaction to adjust speed of 100 rev / min to cool to room temperature. Remove the liquid crystalline fumaric acid, fumaric acid filtration to give crystals, placed in 80 oven bake 4h. Finally get fumaric 353.3g, a yield of 99.5%.

References:

CN103601636,2016,B Location in patent:Paragraph 0034; 0035

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