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ChemicalBook CAS DataBase List Flucloxacillin sodium
1847-24-1

Flucloxacillin sodium synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: hydroxylamine sulfate / methanol / 1 h / 20 - 40 °C
1.2: 24 h / 0 - 20 °C / pH ~ 9.5 / Inert atmosphere
1.3: pH ~ 7 - 7.5
2.1: phosphorus pentachloride / toluene
3.1: ammonium hydroxide / ethyl acetate / pH 2 - 9

References:

VARDHMAN CHEMTECH LIMITED;GUJRAL, Rajinder Singh;JAIN, Suyog WO2012/164355, 2012, A1

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