ChemicalBook CAS DataBase List Felodipine 3,5-DiMethyl Ester

Felodipine 3,5-DiMethyl Ester synthesis

4synthesis methods

Product Name:Felodipine 3,5-DiMethyl Ester
CAS Number:91189-59-2
Molecular formula:C17H17Cl2NO4
Molecular Weight:370.23

105-45-3
652 suppliers
$5.00/5g

6334-18-5 Synthesis

6334-18-5
393 suppliers
$6.00/10g

14205-39-1 Synthesis

14205-39-1
506 suppliers
$6.00/25g

91189-59-2
89 suppliers
$185.00/100mg

Yield: 82.1%

Reaction Conditions:

in methanol at 60; for 10 h;Temperature;Solvent;

Steps:

1 Example 1:
To the reaction flask was added 80 mL of methanol,Under stirring, 2,3-dichlorobenzaldehyde (14 g, 0.08 mol)3-amino crotonic acid methyl ester (9.2 g, 0.08 mol) aAcetoacetate (9.3 g, 0.08 mol),Then heated to 60 ° C,Avoid light reaction for 10h. The reaction solution was poured into a single-necked flask, concentrated at 40 ° C under reduced pressure to dryness, and 80 mL of anhydrous ether was added. The mixture was beaten for 2 hours. The filter was added to 40 mL of methanol, dissolved at 65 ° C, stirred to room temperature, ~ 5 cold overnight, the next day filter,The filter cake was dried in vacuo at 50 ° C to give 24.3 g of the product as a pale yellow solid (i.e., clavuline butyrate), yield 82.1%, purity (HPLC): 98.72%.

References:

Bengbu Fengyuan Pharmaceutical Co., Ltd.;Li Libiao;Zhang Jin;Zheng Ai;Chen Yun;Hu Yuan CN106748974, 2017, A Location in patent:Paragraph 0026-0034

105-45-3
652 suppliers
$5.00/5g

6334-18-5 Synthesis

6334-18-5
393 suppliers
$6.00/10g

91189-59-2
89 suppliers
$185.00/100mg

References

6334-18-5 Synthesis

6334-18-5
393 suppliers
$6.00/10g

91189-59-2
89 suppliers
$185.00/100mg

References