ChemicalBook CAS DataBase List (+)-Ethyl D-lactate

(+)-Ethyl D-lactate synthesis

11synthesis methods

Product Name:(+)-Ethyl D-lactate
CAS Number:7699-00-5
Molecular formula:C5H10O3
Molecular Weight:118.13

(+)-Ethyl D-lactate is a synthetic compound that is used for the synthesis of lactates and other esters. It can be synthesized from ethyl alcohol and lactic acid by titration calorimetry.

64-17-5 Synthesis

64-17-5
725 suppliers
$10.00/50g

18668-00-3
48 suppliers
$44.00/100mg

7699-00-5
138 suppliers
$5.00/1g

Yield:7699-00-5 58%

Reaction Conditions:

with sulfuryl dichloride at -40 - 20; for 48 h;

Steps:

A5.B

Step B: f?)-ethy. 2-hydroxypropanoateTo a solution of (f?)-2-acetoxypropanoic acid (30g, 0.23 mol) in EtOH (500 ml) was added sulfuryl dicbioride (54 g, 0.45mol) dropwise below -40 °C. The mixture was stirred for 48 hours at room temperature. The ethanol was removed under reduced pressure to afford sulfuryl dichloride, which was purified by silica gel chromatography (15 g, 58%). H NMR (400MHz, CDCi₃) δ ppm, 4.22-4.27 (m, 3H), 2.87-2.87 (q, 1 H), 1.41 -1 .43 (d, 3H, J = 7.6 Hz), 1.30-1.32 (m, 3H).

References:

WO2012/92880,2012,A1 Location in patent:Page/Page column 43