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362669-47-4

ETHYL 8-(4-BIPHENYL)-8-OXOOCTANOATE synthesis

3synthesis methods
14002-51-8 Synthesis
4-Biphenylcarbonyl chloride

14002-51-8
192 suppliers
$21.00/1g

103187-95-7 Synthesis
ETHYL 8-OXO-8-PHENYLOCTANOATE

103187-95-7
8 suppliers
$316.00/1g

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Yield:362669-47-4 41%

Steps:

18 Ethyl 7-(4-biphenyl)carbonylheptanoate (49h)

Ethyl 7-(4-biphenyl)carbonylheptanoate (49h) Following a procedure analogous to that described above for 49a, but substituting 4-biphenylcarbonyl chloride for benzoyl chloride, the title compound was obtained as a white solid in 41% yield: 1H NMR (300 MHz, CDCl3) δ8.01 (d, J=7.2 Hz, 2H), 7.39-7.69 (m, 7H), 4.12 (q, J=6.9 Hz, 2H), 2.99 (t, J=7.2 Hz, 2H), 2.30(t, J=7.5 Hz, 2H), 1.76 (m, 2H), 1.65 (m, 2H), 1.40 (m, 4H), 1.25 (t, J=7.2 Hz, 3H).

References:

US2002/115826,2002,A1

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