ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE synthesis
- Product Name:ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE
- CAS Number:890100-51-3
- Molecular formula:C12H10O3S2
- Molecular Weight:266.34
5271-67-0
256 suppliers
$5.00/1g
5751-83-7
151 suppliers
$6.00/1g
890100-51-3
12 suppliers
$512.00/1g
Yield:890100-51-3 68%
Reaction Conditions:
Stage #1: ethyl 5-bromothiophene-2-carboxylatewith diisobutylaluminum chloride in tetrahydrofuran at -78;Inert atmosphere;Schlenk technique;
Stage #2: with n-butyllithium in tetrahydrofuran;hexane at -78 - 20;Inert atmosphere;Schlenk technique;
Stage #3: 2-Thiophenecarbonyl chloridewith copper(I) cyanide di(lithium chloride) in tetrahydrofuran;hexane at -40 - 25;Inert atmosphere;
References:
Klatt, Thomas;Groll, Klaus;Knochel, Paul [Chemical Communications,2013,vol. 49,# 62,p. 6953 - 6955] Location in patent:supporting information