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ChemicalBook CAS DataBase List ETHYL 5-METHYL-5-HEXENOATE
39495-82-4

ETHYL 5-METHYL-5-HEXENOATE synthesis

10synthesis methods
-

Yield:39495-82-4 57%

Reaction Conditions:

Stage #1: diethyl malonatewith sodium hydride in tetrahydrofuran at 0 - 20;Inert atmosphere;
Stage #2: 4-mesyloxy-2-methylbutene in tetrahydrofuran; for 12 h;Inert atmosphere;Reflux;
Stage #3: with sodium chloride in water;dimethyl sulfoxide at 180 - 200; for 12 h;

References:

Fernández-Mateos;Madrazo, S. Encinas;Teijón, P. Herrero;González, R. Rubio [Journal of Organic Chemistry,2015,vol. 80,# 9,p. 4378 - 4391]

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