ETHYL 4-(2,4-DIMETHOXYPHENYL)-4-OXOBUTYRATE synthesis
- Product Name:ETHYL 4-(2,4-DIMETHOXYPHENYL)-4-OXOBUTYRATE
- CAS Number:858445-94-0
- Molecular formula:C14H18O5
- Molecular Weight:266.29
14794-31-1
297 suppliers
$9.00/25g
151-10-0
447 suppliers
$5.00/10g
858445-94-0
12 suppliers
$366.00/1g
Yield:-
Reaction Conditions:
with aluminum (III) chloride in 1,2-dichloro-ethane at 0 - 20; for 1 h;
Steps:
72 Synthesis of Compound 2
Ethyl succinyl chloride (18 g, 0.11 mol) dissolved in 1.2-DCE (1000 ml), the reaction mixture cooled to 0° C., AlCl3 (17.3 g, 0.13 mol) added dropwise with stirring at 0° C., the above suspension added a solution of compound 1 (13.8 g, 0.1 mol) in 200 ml of 1,2-DCE from the dropping funnel over a period of 30 min, the mixture solution stirred at RT for 30 min, TLC (PE:EA=1:1) showed the starting material was consumed completely. The above solution poured into 1000 ml ice-water, the organic layers separated, the aqueous layer was extracted with DCM (500*3), the combined organic layers were washed with sat NaCl (500 ml*2), dried over Na2SO4, the solvent was removed to get the crude compound 2 (16 g, 60%) and use at the next step directly.
References:
JP2015/214548,2015,A Location in patent:Paragraph 1245; 1246
151-10-0
447 suppliers
$5.00/10g
858445-94-0
12 suppliers
$366.00/1g
14617-06-2
15 suppliers
$220.00/100mg
858445-94-0
12 suppliers
$366.00/1g