ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE synthesis
- Product Name:ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE
- CAS Number:1558-81-2
- Molecular formula:C7H9NO2
- Molecular Weight:139.15
Yield:1558-81-2 59.6%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80;
Steps:
CXI
To a stirred mixture of compound CXI-5 (30 g, 0.265 mol), l-bromo-2- chloroethane (75 g, 0.528 mol) in DMF (200 mL) was added K2C03 (110 g, 0.8 mol). The reaction mixture was heated to 80°C overnight. The mixture was diluted with ice water, extracted with hexane, washed with water and brine, dried over Na2S04, filtered and concentrated. The residue was main compound CXI-6 (22 g, yield 59.6%) and used directly.
References:
WO2013/25733,2013,A1 Location in patent:Paragraph 0793
107-06-2
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1558-81-2
159 suppliers
$8.00/1g