(E)-1,1,1-Trichloro-4-ethoxy-but-3-en-2-one synthesis
- Product Name:(E)-1,1,1-Trichloro-4-ethoxy-but-3-en-2-one
- CAS Number:59938-07-7
- Molecular formula:C6H7Cl3O2
- Molecular Weight:217.48
109-92-2
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76-02-8
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59938-07-7
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Yield:-
Reaction Conditions:
at 0 - 135; for 22 h;
Steps:
1 Step 1:
(E)-1,1,1-trichloro-4-ethoxy-but-3-en-2-one
To a solution of 2,2,2-trichloroacetyl chloride (31.52 g, 173.36 mmol, 19 mL, 1 eq) was added dropwise ethyl vinyl ether (25 g, 346.71 mmol, 33 mL, 2 eq) at 0° C.
After addition, the mixture was stirred at this temperature for 5 h, and then the mixture was warmed to 25° C. for 16 h.
The mixture was stirred at 130° C. under reduced pressure to let gas (hydrogen chloride) evaporate to form a deep black color solution.
The process required for 1 h or waited until no gas came out.
The residue was concentrated under reduced pressure.
The crude product (E)-1,1,1-trichloro-4-ethoxy-but-3-en-2-one (39.3 g, crude) was obtained as a black oil.
References:
US2018/125821,2018,A1 Location in patent:Paragraph 1440; 1441
109-92-2
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4124-31-6
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59938-07-7
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$45.00/50mg
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59938-07-7
48 suppliers
$45.00/50mg