dihydro-6-imino-1,3-dimethyluracil synthesis
- Product Name:dihydro-6-imino-1,3-dimethyluracil
- CAS Number:17743-04-3
- Molecular formula:C6H9N3O2
- Molecular Weight:155.15
![2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide](/CAS/GIF/39615-79-7.gif)
39615-79-7
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17743-04-3
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Yield:-
Reaction Conditions:
with acetic acid;sodium hydroxide in water; pH=9.5 at 40 - 92; under 712.571 Torr; for 0.5 h;Temperature;pH-value;
Steps:
1-5
Add 150 mL of water to the reaction solution, add acid with water, and control the temperature to 40°C.The vacuum degree is greater than 0.095MPa, until no fraction is produced. After steaming the acetic acid,Add water to make the volume up to 7000mL, heat up to 85°C ,Add liquid caustic soda until the pH value is 9.5, heat up to 92°C, keep the temperature for 30 minutes,The 1,3-dimethylcyanoacetyl urea in the reaction solution is cyclized to produce 1,3-dimethyl-4-iminouracil.
References:
Shijiazhuang Siyao Co., Ltd.;Hebei Guangxiang Pharmaceutical Co., Ltd.;Han Shuqin;Han Yue;Zhu Shujie;Zhang Weijin;Fu Lihang;Ma Xianguo CN111592548, 2020, A Location in patent:Paragraph 0041; 0043; 0050-0051; 0053; 0065; 0067
