Digitoxin synthesis
- Product Name:Digitoxin
- CAS Number:71-63-6
- Molecular formula:C41H64O13
- Molecular Weight:764.94
![5-Hexyne-2,3-diol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 2-benzoate, (2R,3R,4S)-](/CAS/20210111/GIF/279684-79-6.gif)
279684-79-6
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Yield:-
Steps:
Multi-step reaction with 12 steps
1: PPh3; HBr / toluene / 6 h
2: 99 percent / DIBAL / CH2Cl2 / -78 °C
3: 96 percent / DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation
4: Bu4NF / tetrahydrofuran
5: Et3N; DMAP / CH2Cl2
6: 71 percent / PPh3; HBr / toluene / 6 h
7: 98 percent / DIBAL / CH2Cl2 / -78 °C
8: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation
9: Et3N; DMAP / CH2Cl2
10: PPh3; HBr / CHCl3
11: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C
12: NaOMe / methanol
References:
McDonald, Frank E.;Subba Reddy [Angewandte Chemie - International Edition,2001,vol. 40,# 19,p. 3653 - 3655]
![D-ribo-Hex-1-enitol, 1,5-anhydro-2,6-dideoxy-3,4-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-](/CAS/20211123/GIF/279684-76-3.gif)
279684-76-3
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![D-ribo-Hex-1-enitol, 1,5-anhydro-2,6-dideoxy-4-O-[2,6-dideoxy-3,4-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribo-hexopyranosyl]-3-O-[(1,1-dimethylethyl)dimethylsilyl]-](/CAS/20211123/GIF/279684-92-3.gif)
279684-92-3
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71-63-6
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$35.00/100mg