dexpanthenol synthesis
- Product Name:dexpanthenol
- CAS Number:62507-76-0
- Molecular formula:C9H19NO4
- Molecular Weight:205.2515
50692-78-9
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Yield:62507-76-0 0.128 g
Reaction Conditions:
with lithium aluminium hydride in tetrahydrofuran at 5 - 10; for 1.25 h;
Steps:
1 Reduction of methyl pantothenate with lithium aluminium hydride
A solution of lithium aluminium hydride (2.4M in THF, 0.44 ml) was diluted with THF (1 ml) and cooled to approximately 5°C. A solution of methyl pantothenate (0.2 g, 95% purity) in THF (0.7 ml) was added dropwise over 15 minutes and the reaction mixture was stirred for a further 1 hour at 5-10°C. The mixture was quenched with saturated sodium sulfate solution and the organic layer was separated, dried and evaporated to give 0.128 g of panthenol (94.8% purity by qNMR).
References:
WO2022/219173,2022,A1 Location in patent:Page/Page column 11
