ChemicalBook CAS DataBase List Estradiol Cypionate

Estradiol Cypionate synthesis

2synthesis methods

Product Name:Estradiol Cypionate
CAS Number:313-06-4
Molecular formula:C26H36O3
Molecular Weight:396.57

To a solution of 2.5 grams (18.1 mmol) of potassium carbonate in 25 ml of water was added 225 ml of methanol followed by 5.0 grams (9.6 mmol) of estradiol 3,17β-dicyclopentanepropionate. The mixture was stirred for 2? hours at 202°C during which time some precipitation occurred. The mixture was poured into 700 ml of water with efficient stirring and the precipitated solid was removed by filtration, washed with water and dried.

Recrystallization of the crude product from 80% methanol gave 3.16 grams (83%) of estradiol 17β-cyclopentanepropionate(Estradiol Cypionate) melting at 148° to 151°C. Recrystallization from benzenepetroleum ether raised the MP to 151° to 152°C.

50-28-2 Synthesis