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ChemicalBook CAS DataBase List Decanoyl chloride
112-13-0

Decanoyl chloride synthesis

5synthesis methods
-

Yield:112-13-0 100%

Reaction Conditions:

with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 0 - 20; for 4 h;

Steps:

a a) Decanoyl chloride
To a cooled (0 °C) solution of decanoic acid (275 mg, 1.59 mmol) in DCM (8 mL) was added dropwise oxalyl chloride (0.56 mL, 6.39 mmol) and DMF (3 drops) and the mixture was stirred at room temperature for 4 h. The solvent was removed under reduced pressure to yield the title compound as a yellow oil (315 mg, 100%) which was used in the next synthetic step without further purification.

References:

ALMIRALL, S.A.;BACH TA?A, Jordi;ESTEVE TRIAS, Cristina;MIR CEPEDA, Marta WO2019/115405, 2019, A1 Location in patent:Page/Page column 48

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