成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Cyclopropylacetic acid
5239-82-7

Cyclopropylacetic acid synthesis

11synthesis methods
-

Yield:5239-82-7 475.6 mg

Reaction Conditions:

Stage #1: Cyclopropylacetylenewith n-butyllithium in tetrahydrofuran at -78; for 1 h;
Stage #2: with 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; for 2 h;
Stage #3: with oxone in acetone at 50; for 12 h;

Steps:

1 Example 1

At -78 ° C, n-butyllithium (2.4 mL, 2.5 mol / L, 1.2 equivalents) was added dropwise to a tetrahydrofuran solution (15 mL) of cyclopropyne (330.5 mg, 1.0 equivalent), and reacted for 1 h.Then isopropanol pinacol borate (1.2 mL, 1.2 equivalents) was added dropwise to the mixed solution,Continue to react for 2h,Quenched with 1,4-dioxane solution (1.9mL, 4M in dioxane, 1.5 equivalents) and quenched. The reaction was warmed to room temperature. After the solvent was rotary evaporated, it was prepared into an acetone solution (0.3M).Add potassium peroxymonosulfonate solution (0.5M, 4.6107g, 1.5 equivalents),Transfer to 50 ° C. and stir for 12 h, then isolate and purify to obtain 475.6 mg of cyclopropaneacetic acid with a purity of 95%.

References:

CN110330420,2019,A Location in patent:Paragraph 0033-0037

Cyclopropylacetic acid Related Search: