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62587-07-9

CYCLOPROPYL 4-TRIFLUOROMETHYLPHENYL KETONE synthesis

13synthesis methods
147356-78-3 Synthesis
N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE

147356-78-3
85 suppliers
$25.00/1g

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Yield:62587-07-9 89%

Reaction Conditions:

Stage #1: p-trifluoromethylphenyl bromidewith n-butyllithium in tetrahydrofuran;hexane at -78; for 0.5 h;Inert atmosphere;
Stage #2: N-methoxy-N-methylcyclopropanecarboxamide in tetrahydrofuran;hexane at -78 - 20; for 2 h;Inert atmosphere;

References:

Cui, Ning;Lin, Tingzhi;Wang, Yan-En;Wu, Jian;Han, Yuheng;Xu, Xinyang;Xue, Fei;Xiong, Dan;Walsh, Patrick J.;Mao, Jianyou [Organic Letters,2022,vol. 24,# 22,p. 3987 - 3992] Location in patent:supporting information

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