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6602-64-8

CYCLOHEXYL 2-PYRIDYL KETONE synthesis

9synthesis methods
-

Yield:6602-64-8 80%

Reaction Conditions:

Stage #1: 2-bromo-pyridinewith n-butyllithium in tetrahydrofuran;hexane at -78; for 0.5 h;
Stage #2: cyclohexanecarbaldehyde in tetrahydrofuran;hexane at -78; for 2 h;
Stage #3: with iodine;potassium carbonate in tert-butyl alcohol; for 14 h;Reflux;

References:

Ushijima, Sousuke;Dohi, Souya;Moriyama, Katsuhiko;Togo, Hideo [Tetrahedron,2012,vol. 68,# 5,p. 1436 - 1442] Location in patent:scheme or table

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