Cyclohexanol, 1-(2-bromophenyl)- synthesis
1synthesis methods
- Product Name:Cyclohexanol, 1-(2-bromophenyl)-
- CAS Number:255837-16-2
- Molecular formula:C12H15BrO
- Molecular Weight:255.15
Yield:255837-16-2 70%
Reaction Conditions:
Stage #1: 2,3-dibromobenzenewith n-butyllithium in tetrahydrofuran;diethyl ether;hexane at -110; for 1.75 h;Inert atmosphere;
Stage #2: cyclohexanone in tetrahydrofuran;diethyl ether;hexane at -110 - 20; for 13 h;Inert atmosphere;
References:
Kinoshita, Hidenori;Hirai, Nobuyoshi;Miura, Katsukiyo [Journal of Organic Chemistry,2014,vol. 79,# 17,p. 8171 - 8181]