Cyclohexane, 1-bromo-1-methyl- synthesis

10synthesis methods

Product Name:Cyclohexane, 1-bromo-1-methyl-
CAS Number:931-77-1
Molecular formula:C7H13Br
Molecular Weight:177.08

591-49-1 Synthesis

591-49-1
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931-77-1
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Yield:931-77-1 98 %Spectr.

Reaction Conditions:

with hydrogen bromide;silica gel in water at 0 - 20; for 48 h;Reagent/catalyst;

Steps:

General procedure for the hydrobromination of alkene 1a with hydrobromic acid mediated by silica gel

General procedure: 47% Hydrobromic acid (1.38 g, 8.0mmol) was gradually added to a mixture of 1a (280 mg, 2.0 mmol)and silica gel 60 (63-200 μm, spherical, Nacalai Tesque, 5.0g) in a 25 mL flask at 0 °C. After stirring the mixture at 300 rpm until it fully mixes, the mixture was treated in a manner similar to the procedure described above to give 3a (380 mg, 86%).

References:

Tanemura, Kiyoshi [Tetrahedron Letters,2018,vol. 59,# 49,p. 4293 - 4298] Location in patent:supporting information

590-67-0 Synthesis