chloroacetyl-ure synthesis
- Product Name:chloroacetyl-ure
- CAS Number:4791-21-3
- Molecular formula:C3H5ClN2O2
- Molecular Weight:136.54
Yield:4791-21-3 91%
Reaction Conditions:
in toluene; for 2 h;Reflux;
Steps:
74
To a mixture of urea (5.00 g, 83.0 mmol) in anhydrous toluene (13 mL) was added chloroacetyl chloride (6.6 mL, 83.0 mmol) and the reaction mixture was heated to reflux for 2 hours. The reaction mixture was cooled to room temperature and toluene was removed by filtration. The resulting solid was further washed with toluene (10 mL) and mixed with water (100 mL). The solid was filtrated and washed with cold water (50 mL) and dried to give (2-chloroacetyl)-urea as a white solid. Yield: 10.3 g (91%)
References:
US2013/281399,2013,A1 Location in patent:Paragraph 0643
4461-30-7
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$47.00/1g
4791-21-3
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$50.00/50mg
