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Chlorambucil synthesis
- Product Name:Chlorambucil
- CAS Number:305-03-3
- Molecular formula:C14H19Cl2NO2
- Molecular Weight:304.21
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2033-24-1
659 suppliers
$6.00/25g
![Benzeneacetaldehyde, 4-[bis(2-chloroethyl)amino]-](/CAS/20200611/GIF/500590-36-3.gif)
500590-36-3
0 suppliers
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305-03-3
238 suppliers
$28.00/250mg
Yield:305-03-3 76.9%
Reaction Conditions:
with formic acid;triethylamine at 50 - 95; for 5 h;Temperature;
Steps:
2.4 Example 2
(4) 304 g of triethylamine was slowly added dropwise to 680 g of the 920 formic acid system.After 5 h, the reaction was stirred at 50 °C for 2 h. To the system, 156 g of 4-[bis(2-chloroethyl)amino]phenylacetaldehyde was added in 7 batches.Lastly, we added 87g of Mie acid,The temperature was raised to 95 °C and the reaction was completed for 5 h. Transfer the system to water,Extract twice with 500 g of dichloromethane, wash once with 1000 g of water, and wash once with 500 g of saturated brine.The organic phase was separated, dried, and the solvent was evaporated in vacuo to give 172 g of a crude oil.Recrystallization from a mixed solvent of 500 g of dichloromethane and 200 g of petroleum ether gave 139 g of chlorambucil.White crystals.Yield 76.9%,The content is 99.2%.
References:
CN107628962,2018,A Location in patent:Paragraph 0027; 0039; 0040; 0045
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79481-83-7
14 suppliers
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305-03-3
238 suppliers
$28.00/250mg
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20637-02-9
7 suppliers
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305-03-3
238 suppliers
$28.00/250mg
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20637-09-6
84 suppliers
$18.00/100mg
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305-03-3
238 suppliers
$28.00/250mg
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130198-76-4
13 suppliers
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305-03-3
238 suppliers
$28.00/250mg