Benzenamine, 4,5-difluoro-N-methyl-2-nitro- synthesis
1synthesis methods
- Product Name:Benzenamine, 4,5-difluoro-N-methyl-2-nitro-
- CAS Number:279231-42-4
- Molecular formula:C7H6F2N2O2
- Molecular Weight:188.13
Yield:279231-42-4 81%
Reaction Conditions:
in tetrahydrofuran at -20; for 1 h;
Steps:
86.a
(a) 4,5-Difluoro-//-methyl-2-nitroanilineA solution of MeNH2 in THF (5.7 mL, 2 M, 11 mmol) was added dropwise to a solution of 1 ,2,4-trifluoro-5-nitrobenzene (1.0 g, 5.7 mmol) in THF (10 mL) at -20 °C. The mixture was stirred at -20 °C for 1 h, concentrated, washed with brine and extracted with EtOAc. The organic layer was dried over Na2S04, filtered and concentrated. Crystallization fromEtOAc/PE gave the sub-title compound. Yield: 1.0 g (81 %).
References:
WO2012/76672,2012,A1 Location in patent:Page/Page column 87