ChemicalBook CAS DataBase List Bardoxolone

Bardoxolone synthesis

12synthesis methods

Product Name:Bardoxolone
CAS Number:890707-28-5
Molecular formula:C9H11ClN2O
Molecular Weight:198.65

870997-57-2
69 suppliers
$45.00/100mg

890707-28-5
160 suppliers
$5.00/100mg

Yield:890707-28-5 85%

Reaction Conditions:

with hydrogenchloride;dihydrogen peroxide;acetic acid at 5 - 20;

Steps:

Step-4 : 2-Amino-5-chloro-N,3-dimethylbenzamide
To a solution of 2-amino-N,3-dimethylbenzamide (4 g, 0.023) and hydrochloric acid (8 ml) in acetic acid (12 ml) was added hydrogen peroxide (30%, 0.032 mol) at 5-10°C. The reaction mixture was stirred for 5-6 h at room temperature. The progress of the reaction was monitored by HPLC. After completion of the reaction, water was added into the reaction mixture. The resultant solid product was isolated by filtration and washed with water. Yield: 85% and purity: 95%.

References:

EUROFINS ADVINUS LIMITED WO2021/33172, 2021, A1 Location in patent:Page/Page column 9; 16-17

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20776-67-4 Synthesis