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ChemicalBook CAS DataBase List Apremilast
1384440-16-7

Apremilast synthesis

1synthesis methods
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Apremilast

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Yield:-

Reaction Conditions:

with trimethylsilyl iodide in dichloromethane at 20; for 24 h;

Steps:

5.7

5.7 (S)-4-Amino-2-[1-(3-ethoxy-4-hydroxy-phenyl)-2-methanesulfonyl-ethyl]-isoindole-1,3-dione To a stirred solution of (S)-4-amino-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-isoindole-1,3-dione (1 mmol) in anhydrous CH2Cl2 (20 mL), is added iodotrimethylsilane (6 mmol). The mixture is stirred at room temperature for 24 hours. The reaction mixture is diluted with brine and is extracted with CH2Cl1). The solvent is removed in vacuo to afford crude (S)-4-amino-2-[1-(3-ethoxy-4-hydroxy-phenyl)-2-methanesulfonyl-ethyl]-isoindole-1,3-dione. The product is purified by recrystallization.

References:

US2012/178708,2012,A1 Location in patent:Page/Page column 20

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