ChemicalBook CAS DataBase List Anilinoacetic acid

Anilinoacetic acid synthesis

10synthesis methods

Product Name:Anilinoacetic acid
CAS Number:103-01-5
Molecular formula:C8H9NO2
Molecular Weight:151.16

N-Phenylglycine can be used for the colorimetric determination of copper, an intermediate of indigo, and also for biochemical research. It was prepared from L-phenylglycine and D-phenylglycine amide by stirring in H2O with n-butanol for 1 h at 70℃.

21969-70-0 Synthesis

21969-70-0
31 suppliers
$125.00/500 mg

71-36-3 Synthesis

71-36-3
1044 suppliers
$14.00/25mL

103-01-5
294 suppliers
$10.64/5G

Yield:103-01-5 90%

Steps:

14 EXAMPLE 14
EXAMPLE 14 An aqueous solution containing L-phenylglycine and D-phenylglycine amide, 295 g, obtained in Reference Example 3 was vacuum concentrated to 100 g. Thereafter, 190 g of n-butanol was added to the solution. The solution was vacuum concentrated to 110 g, 190 g of n-butanol was added again, and vacuum concentration was continued until 120 g of concentrate was finally obtained. After 30 g of n-butanol was added to the concentrate, the water content of the solution was 0.1% by mass. After this n-butanol solution was stirred at 70° C. for 1 hour, the solution was cooled and stirred at 20° C. for an additional 5 hours. Precipitated crystals were collected by suction filtration and 13.5 g (dry mass) of L-phenylglycine was obtained (yield 90%). The amount of D-phenylglycine amide contained in crystalline L-phenylglycine was 0.05% by mass.

References:

Katoh, Osamu;Uragaki, Toshitaka;Nakamura, Tetsuji US2003/171597, 2003, A1