ChemicalBook CAS DataBase List Amiodarone hydrochloride

Amiodarone hydrochloride synthesis

11synthesis methods

Product Name:Amiodarone hydrochloride
CAS Number:19774-82-4
Molecular formula:C25H29I2NO3.ClH
Molecular Weight:681.77

869-24-9 Synthesis

2-Diethylaminoethylchloride hydrochloride

869-24-9
5 suppliers
$10.00/1g

2-Butyl-3-(3,5-Diiodo-4-hydroxy benzoyl) benzofuran

1951-26-4
255 suppliers
$2.50/1g

19774-82-4
446 suppliers
$10.00/250mg

Yield:19774-82-4 88%

Reaction Conditions:

with potassium carbonate in water;toluene; for 10 h;Reflux;Solvent;Reagent/catalyst;

Steps:

1-4

The compound of formula 4 above (46.4g, 85mmol) was dissolved in toluene (450mL), and then N,N-diethylchloroethylamine hydrochloride (19.1g, 111mmol), potassium carbonate (21.8g, 158mmol) and water were added (40mL), reflux and react for 10 hours.After the completion of the reaction, the organic layer was washed with water, and the pH of the organic phase was adjusted to 1-2 with HCl/MeOH, and then most of the solvent was evaporated and left to cool to precipitate 51 g of amiodarone hydrochloride with a yield of 88%.

References:

CN113527236,2021,A Location in patent:Paragraph 0035; 0038; 0039; 0042; 0043; 0046; 0047; 0050