1-(4-METHYL-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID synthesis
- Product Name:1-(4-METHYL-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
- CAS Number:96449-91-1
- Molecular formula:C13H15NO3
- Molecular Weight:233.26
97-65-4
539 suppliers
$5.00/25g
104-86-9
280 suppliers
$6.00/5g
96449-91-1
25 suppliers
$64.00/250mg
Yield:96449-91-1 92%
Reaction Conditions:
at 120; for 4 h;
Steps:
64-1 (64-1)
(64-1)
Synthesis of 1-[(4-chlorophenyl)methyl]-5-pyrrolidine-3-carboxylic acid (Compound 64-1)
A mixture of itaconic acid (1.3 g, 10 mmol) and p-chlorobenzylamine (1.28 ml, 11 mmol) was stirred at 120 °C for 4 hours.
Thereafter, the solvent was evaporated off under reduced pressure, and the obtained crystals were washed with a mixed solution of acetic acid and hexane (1:9) to obtain the title compound (2.3 g, yield 92%).
References:
EP3275440,2018,A1 Location in patent:Paragraph 0155; 0156
97-65-4
539 suppliers
$5.00/25g
104-84-7
222 suppliers
$21.00/5g
96449-91-1
25 suppliers
$64.00/250mg