ChemicalBook CAS DataBase List N-[(1R,2R)-1,2,3,4-TETRAHYDRO-1-HYDROXY-7-METHOXY-2-NAPHTHALENYL]PROPANAMIDE

N-[(1R,2R)-1,2,3,4-TETRAHYDRO-1-HYDROXY-7-METHOXY-2-NAPHTHALENYL]PROPANAMIDE synthesis

5synthesis methods

Product Name:N-[(1R,2R)-1,2,3,4-TETRAHYDRO-1-HYDROXY-7-METHOXY-2-NAPHTHALENYL]PROPANAMIDE
CAS Number:88058-70-2
Molecular formula:C14H19NO3
Molecular Weight:249.31

6836-19-7
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N-[(1R,2R)-1,2,3,4-TETRAHYDRO-1-HYDROXY-7-METHOXY-2-NAPHTHALENYL]PROPANAMIDE

88058-70-2
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Yield:-

Steps:

Multi-step reaction with 5 steps
1: potassium tert-butoxide, isoamyl nitrite / diethyl ether; butan-1-ol / 4 h / Ambient temperature
2: H₂ / 10percent Pd/C / tetrahydrofuran
3: 55 percent / sodium borohydride / ethanol
4: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / 1 h
5: 87 percent / KOH / ethanol; H₂O / 0.25 h / 50 °C

References:

Jones;Anderson;Baldwin;Clineschmidt;McClure;Lundell;Randall;Martin;Williams;Hirshfield [Journal of Medicinal Chemistry,1984,vol. 27,# 12,p. 1607 - 1613]

766-51-8 Synthesis