Benzoic acid, 2,3-difluoro-4-methyl-, ethyl ester (9CI) synthesis
- Product Name:Benzoic acid, 2,3-difluoro-4-methyl-, ethyl ester (9CI)
- CAS Number:773135-56-1
- Molecular formula:C10H10F2O2
- Molecular Weight:200.18
64-17-5
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Yield:773135-56-1 95%
Reaction Conditions:
with thionyl chloride at 60; for 16 h;
Steps:
Intermediate compound 254: ethyl 2,3-difluoro-4-methylbenzoate
To a solution of 2,3-difluoro-4-methylbenzoic acid (17.43mmol, 3000 mg) in EtOH (20 ml) thionyl chloride (31 .4 mmol, 2.29 ml) was added. The mixture was stirred at 605C for 16h. Solvent was evaporated. It was washed twice with EtAcO/water. The combined organic layers were dried over Na2S04, filtered and evapotared. (3330 mg, yield: 95%). LC-MS: tR = 2.52 [M+H]+ = 201 (method 6)
References:
WO2013/149997,2013,A1 Location in patent:Page/Page column 149