成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 11-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPIN HYDROCHLORIDE
753475-15-9

11-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPIN HYDROCHLORIDE synthesis

3synthesis methods
-

Yield:753475-15-9 90%

Reaction Conditions:

Stage #1: dibenzo[b,f][1,4]thiazepin-11-onewith trichlorophosphate in toluene at 10; for 4 h;Heating / reflux;
Stage #2: with potassium carbonate in water;toluene at 15;
Stage #3: piperazinewith hydrogenchloridemore than 3 stages;

Steps:

a

a) ll-piperazinyl-dibenzo[b,f][l,4] thiazepine dihydrochloride (IV)Dibenzo[b,fj[l,4] thiazepin-l l-[10H]one 100 gm, phosphorus oxychloride 125 ml, N5N- dimethyl aniline 33 ml in toluene 500 ml were refluxed for 4 hour. Toluene was distilled off under vacuum to obtain residue. The residue was dissolved in 250 ml toluene and the reaction mixture was cooled to 100C. Aqueous Potassium carbonate solution (100 g in 200 ml water) was added to the reaction mixture below 150C. The toluene layer was separated and refluxed with piperazine 100 g for 24 hour. The reaction mixture was cooled and filtered to remove unreacted piperazine. Toluene was distilled off under vacuum. The residue was dissolved in 390 ml of isopropyl alcohol. 100 ml of 33% ethanolic hydrochloride was added to the reaction mixture at 25-35° C. White solid obtained was filtered, washed with 100 ml ethanol and dried at 60-700C. Yield : 138 g (90 %).

References:

WO2007/4234,2007,A1 Location in patent:Page/Page column 12