2-[(1R)-2-HYDROXY-1-METHYLETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE synthesis
- Product Name:2-[(1R)-2-HYDROXY-1-METHYLETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE
- CAS Number:73323-91-8
- Molecular formula:C11H11NO3
- Molecular Weight:205.21
Yield:73323-91-8 91%
Reaction Conditions:
with triethylamine in toluene; for 20 h;Reflux;
Steps:
21
A solution of R-alaminol (4.4 g, 58.6 mmol), phthalic anhydride (8.7 g, 58.6 mmol) and TEA (2.73 mL, 20 mmol) in 100 mL of toluene was heated at reflux with azeotropic removal of H2O with a Dean-Stark trap for 20 h. The solution was concentrated under reduced pressure. To the resulting residue was added 5 mL ether. When crystallization was complete, the solid was collected, washed with 5 mL hexanes and dried under vacuum to afford 2-((R)-2-hydroxy-1-methyl-ethyl)isoindole-1,3-dione (10.96 g, 91%).
References:
US2012/157494,2012,A1 Location in patent:Page/Page column 27-28
73365-03-4
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