Yield:417724-81-3 93%

Reaction Conditions:

with ammonia in water at 70; for 2 h;Large scale;

Steps:

1 Synthesis of 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxamide (compound of formula II)
Mix 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid methyl ester (1kg, 4.29mol), Ammonia (10L) and water (10L) were added to the reaction flask and heated to 70°C for 2h. Cooled to room temperature, filtered, the filter cake was washed with water (10L) and tetrahydrofuran (10L), and dried to obtain 0.87kg of 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxamide , The yield is 93%. The purity is 98.51%.

References:

Sichuan Yinuo Dabo Pharmaceutical Technology Co., Ltd.;Dai Zhidong;Fu Qingquan;Wan Hua;Luo Hong;Liu Zhengchao;Zhang Juhua;Wang Ting CN112194623, 2021, A Location in patent:Paragraph 0012; 0026-0028

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