5-METHOXY-2-METHYL-3-(3-SULFOPROPYL)BENZOTHIAZOLIUM INNER SALT synthesis
- Product Name:5-METHOXY-2-METHYL-3-(3-SULFOPROPYL)BENZOTHIAZOLIUM INNER SALT
- CAS Number:63149-01-9
- Molecular formula:C12H15NO4S2
- Molecular Weight:301.38
1120-71-4
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Yield:63149-01-9 84%
Reaction Conditions:
in toluene;Reflux;
Steps:
2.2 Synthesis of 3-(2-methyl-5-methoxybenzothiazole) propane-1-sulfonate
The synthetic route of 3-(2-methyl-5-methoxybenzothiazole) propane-1-sulfonate is shown in Scheme 1 . A 250mL circular bottom flask was taken and 2-methyl-5-methoxybenzothiazole (0.90g, 0.005mol) was measured and dissolved in toluene (20mL). After stirring for 30min, 1, 3-propanolactone (1.00g, 0.008mmol) was added. The reaction mixture was refluxed overnight. The precipitate produced was filtered at room temperature and washed with acetone and ethyl acetate and eventually dried to yield the white powder (84%), namely intermediate. 1H NMR (400MHz, DMSO-d6) δ 8.25 (d, J=9.0Hz, 1H), 8.12 (s, 1H), 7.39 (d, J=6.8Hz, 1H), 4.92 (t, J=8.2Hz, 2H), 3.96 (s, 3H), 3.16 (s, 3H), 2.63 (t, J=6.2Hz, 2H), 2.22-2.09 (m, 2H).
References:
Huang, Minyan;Li, Zhongyu;Xu, Song;Zhang, Yuzhe;Zheng, Xudong;Zhou, Jintao [Inorganic Chemistry Communications,2020,vol. 117]