ChemicalBook CAS DataBase List (3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZIN-2-YL)ACETIC ACID

(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZIN-2-YL)ACETIC ACID synthesis

12synthesis methods

Product Name:(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZIN-2-YL)ACETIC ACID
CAS Number:6270-74-2
Molecular formula:C10H9NO3S
Molecular Weight:223.25

108-31-6 Synthesis

108-31-6
846 suppliers
$13.47/50g

137-07-5
301 suppliers
$10.00/5g

(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZIN-2-YL)ACETIC ACID

6270-74-2
55 suppliers
$24.10/1G

Yield:6270-74-2 98%

Reaction Conditions:

in diethyl ether at 25;Inert atmosphere;regioselective reaction;

Steps:

2-(3-Oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetic Acid (5)

To a stirred solution of maleic anhydride (4, 2.45 g, 25 mmol) in Et₂O (40 mL) was added o-aminothiophenol (2, 3.13 g, 25 mmol) in a dropwise fashion at 25 °C under argon; the mixture was stirred for 1 h. The separated precipitate was filtered on a Buchner funnel and washed with Et₂O (25 mL). The obtained product was dried under vacuum to give pure acid 5; yield: 5.50 g (98%); mp 181-182 °C (MeOH).

References:

Jangir, Ravi;Gadre, Smita R.;Argade, Narshinha P. [Synthesis,2015,vol. 47,# 17,art. no. SS-2015-Z0050-OP,p. 2631 - 2634]

110-16-7 Synthesis