7-(trifluoromethyl)-1,2,3,4-tetrahydro-5-nitroisoquinoline hydrochloride synthesis
- Product Name:7-(trifluoromethyl)-1,2,3,4-tetrahydro-5-nitroisoquinoline hydrochloride
- CAS Number:625126-83-2
- Molecular formula:C10H9F3N2O2
- Molecular Weight:246.19
625126-84-3
0 suppliers
inquiry
625126-83-2
34 suppliers
inquiry
Yield:-
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane; for 1 h;
Steps:
26.B
Step B; The above intermediate from Step A (17.0 g) was dissolved in 100 mL of 4 M HCl/dioxane, stirred for one hour, evaporated and dried under vacuum. Intermediate 26 was obtained as white solid. 1H NMR (400 MHz, CD3OD) δ 8.75 (s, 1H), 8.00 (s, 1H), 2.58 (s, 2H), 3.57 (t, J=6.0 Hz, 2H), 3.42 (t, J=6.0 Hz, 2H).
References:
US2008/81803,2008,A1 Location in patent:Page/Page column 40