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ChemicalBook CAS DataBase List 6-PHENOXYNICOTINIC ACID
51362-38-0

6-PHENOXYNICOTINIC ACID synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: diazomethyl-trimethyl-silane / toluene / 0.5 h
2: caesium carbonate; potassium carbonate / acetonitrile; N,N-dimethyl-formamide / Reflux
3: lithium hydroxide / methanol; water

References:

Kormos, Chad M.;Jin, Chunyang;Cueva, Juan Pablo;Runyon, Scott P.;Thomas, James B.;Brieaddy, Lawrence E.;Mascarella, S. Wayne;Navarro, Hernán A.;Gilmour, Brian P.;Carroll, F. Ivy [Journal of Medicinal Chemistry,2013,vol. 56,# 11,p. 4551 - 4567]

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