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ChemicalBook CAS DataBase List 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
5952-93-2

1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER synthesis

5synthesis methods
-

Yield:5952-93-2 90%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20; for 1 h;

Steps:

131.1 first step 1-methyl-1H-pyrazole-4-carboxylate methyl ester

Methyl pyrazole-4-carboxylate 131a (5 g, 39.65 mmol) was dissolved in N,N-dimethylformamide (50 mL),Potassium carbonate (10.96 g, 79.29 mmol) and methyl iodide (6.19 g, 43.61 mmol) were sequentially added, and the reaction was stirred at room temperature for 1 hour.Water (50 mL) was added, extracted with ethyl acetate (50 mL×3), the organic phases were combined, washed successively with water (50 mL) and saturated sodium chloride solution (50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure.The obtained residue was further separated and purified by silica gel column chromatography (eluent: system A),1-Methyl-1H-pyrazole-4-carboxylate methyl ester 131b (5.04 g) was obtained, yield: 90%.

References:

WO2022/57849,2022,A1 Location in patent:Page/Page column 166-167

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