1-Piperazinecarboxylicacid,4-methyl-,ethylester(6CI,9CI) synthesis
- Product Name:1-Piperazinecarboxylicacid,4-methyl-,ethylester(6CI,9CI)
- CAS Number:59325-11-0
- Molecular formula:C8H16N2O2
- Molecular Weight:172.22
Yield:59325-11-0 65.5%
Reaction Conditions:
with sodium cyanide in dichloromethane at 0 - 20; for 2 h;
Steps:
2 Example 2: The preparation method of ethyl 4-methylpiperazine-1-carboxylate
1. Add 10 g of 4-methylpiperazine-1-formyl chloride hydrochloride and 50 ml of dichloromethane into the reaction flask, then add 5 ml of ethanol, and then cool down to 0-5 °C, add 2 g of sodium cyanide in batches, add After completion, return to room temperature and stir for 2h.2. After adding 50 ml of water to the system, adjust the pH to 6.4 with 4M dilute hydrochloric acid, stir at room temperature, separate the liquid, and keep the water phase.3. The aqueous phase was adjusted to pH 9 with an aqueous sodium carbonate solution, extracted twice with 50 ml of dichloromethane, the organic phases were combined and dried, and the organic phase was spin-dried at 40°C in vacuo to obtain 4-methylpiperazine-1-ethyl formate 5.7 g as a light yellow transparent oil.Yield 65.5%, purity 98.8%.
References:
CN114763342,2022,A Location in patent:Paragraph 0056-0061