ChemicalBook CAS DataBase List 5-Hydroxy-1-indanone

5-Hydroxy-1-indanone synthesis

11synthesis methods

Product Name:5-Hydroxy-1-indanone
CAS Number:3470-49-3
Molecular formula:C9H8O2
Molecular Weight:148.16

5111-70-6 Synthesis

5111-70-6
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$34.00/5g

3470-49-3
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$10.00/1g

Yield:3470-49-3 90%

Reaction Conditions:

AlCl₃ in benzene

Steps:

6 (1S,5R,6S,8R)-6-(1-Hydroxyethyl)-2-(1-indanone-5-yloxy-methyl)-1methylcarbapenem-3-carboxylic acid sodium salt
The starting material was prepared as follows: To a solution of 5-methoxy-1-indanone (2 g, 12.3 mmol) in benzene (50 ml) was added AlCl₃ (4 g, 31 mmol). The mixture was heated at reflux for 5 hours and extracted with ethyl acetate. The organic phase was evaporated and purified by flash chromatography, eluding with CH₂ Cl₂ /CH₃ CN (90/10) to give 5-hydroxy-1-indanone as a yellow solid (1.65 g; 90%). ¹ H-NMR (DMSO-d₆): δ 2.58-2.67 (m, 2H); 2.94-3.01 (m, 2H); 6.79 (dd, 1H), 6.84 (s, 1H); 7.4.7 (d, 1H).

References:

Zeneca Limited;Zeneca Pharma SA US5607928, 1997, A

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35999-20-3 Synthesis