5-ETHYL-2-METHOXY-BENZENESULFONYL CHLORIDE synthesis
- Product Name:5-ETHYL-2-METHOXY-BENZENESULFONYL CHLORIDE
- CAS Number:88040-88-4
- Molecular formula:C9H11ClO3S
- Molecular Weight:234.7
1515-95-3
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88040-88-4
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$45.00/10mg
Yield:88040-88-4 53%
Reaction Conditions:
with chlorosulfonic acid at 0 - 20; for 2 h;
Steps:
x 5-ethyl-2-methoxybenzenesulfonyl chloride I19
1-Ethyl-4-methoxybenzene (5.0 g, 37 mmol) was added dropwise to chlorosulfonic acid (20 ml.) at 0 °C and the mixture was stirred at room temperature for 2 h then poured onto ice and extracted with EtOAc (50 ml. x 3). The combined organic extracts were dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (petroleum ether/EtOAc = 100/1 to 30/1) to give the title compound I19 (4.6 g, 53%) as a white solid. LCMS-B (ES-API): Rt2.70 min; m/z 256.9 [M+Na]+.
References:
WO2020/2587,2020,A1 Location in patent:Page/Page column 63-64
123-07-9
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88040-88-4
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$45.00/10mg