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ChemicalBook CAS DataBase List 5-Chloro-2-fluoroaniline
2106-05-0

5-Chloro-2-fluoroaniline synthesis

2synthesis methods
-

Yield:-

Reaction Conditions:

with 5%-palladium/activated carbon;hydrazine hydrate in methanol at 80; for 0.0833333 h;Overall yield = 25 %;

Steps:

General Procedures; Method A:

General procedure: To a mixture ofhalogenated nitroarene (1 mmol), Pd/C(5%), and MeOH (5mL) was added NH2NH2·H2O (10 mmol), and the resultingsolution was heated at 80 °C reflux condition for 5 min. Thenthe mixture was filtered and concentrated in vacuo. Thecrude material was purified by flash column

References:

Li, Fang;Frett, Brendan;Li, Hong-Yu [Synlett,2014,vol. 25,# 10,art. no. ST-2014-R0200-L,p. 1403 - 1408]

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