(5-bromopyridin-2-yl)isopropylamine synthesis
- Product Name:(5-bromopyridin-2-yl)isopropylamine
- CAS Number:443339-43-3
- Molecular formula:C8H11BrN2
- Molecular Weight:215.09
766-11-0
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$6.00/5g
75-31-0
431 suppliers
$14.00/25mL
443339-43-3
20 suppliers
$90.00/50mg
Yield:443339-43-3 74%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide at 20 - 120; for 2 h;
Steps:
339.1 Step 1:
5-bromo-N-isopropyl-pyridin-2-amine
To a stirred solution of 5-bromo-2-fluoro-pyridine (1 g, 5.7 mmol) in DMSO (10 mL) were added propan-2-amine (2 g, 33.8 mmol) and DIEA (2.7 mL, 15.5 mmol) at room temperature.
The reaction was stirred at 120° C. for 2 h.
The resulting solution was cooled to room temperature and purified by reverse-phase column chromatography to afford the title compound (900 mg, 74% yield) as a yellow solid. LCMS (M+H)+ 215.
References:
US2018/296543,2018,A1 Location in patent:Paragraph 0717; 0718
1072-97-5
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67-64-1
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$19.10/10ml
443339-43-3
20 suppliers
$90.00/50mg